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🏷️ Science — Dramatic improvement of neuromyotonia (Isaacs' syndrome) with THC in a case report
According to a case report from a hospital in Nantes, France, oral THC (dronabinol) improved the symptoms of a patient with Isaacs' syndrome, which did not respond to other treatments. A 56-year-old man presented with episodes of profuse sweating associated with muscular twitching that began one year before the first assessment in the hospital. Bouts of drenching sweats occurred 2 or 3 times a day, lasted from 20 minutes to 2 hours and were associated with intense itching on body truck. Body weight had decreased from 70 to 55 kg during that period. He presented with prominent generalized myokymia, i.e. involuntary, spontaneous, localized quivering of a few muscles bundles within a muscle. Antibodies to transmembrane channels specific for potassium were highly increased. Several medications and treatments, including intravenous immunoglobulins, were tried to reduce symptoms, but were all ineffective. Finally, THC was titrated up progressively to 20 mg/day over a one month period and used as a monotherapy.