Você esta aqui:Home > Therapeutics (antigo) > Effects of Smoked Marijuana on the Lung and Its Immune Defenses: Implications for Medicinal Use in HIV-Infected Patients

J Cannabis Ther 2001(3/4):087-102

Smoking and the Lung

Effects of Smoked Marijuana on the Lung and Its Immune Defenses: Implications for Medicinal Use in HIV-Infected Patients

Author
D.P. Tashkin

Abstract
Habitual marijuana smoking may cause a number of potentially harmful effects on the lung, including the following: (1) acute and chronic bronchitis; (2) extensive histopathologic alterations in the cells lining the bronchial passages that could impair mucociliary clearance or predispose to malignancy; (3) increased accumulation of inflammatory cells (alveolar macrophages) in the lung; and (4) impairment in the function of these important immune-effector cells, including their ability to kill microorganisms and to produce protective pro-inflammatory cytokines. The major potential pulmonary consequences of habitual marijuana use are pulmonary infection and respiratory cancer. Infectious complications could be due to smoking-related damage to the mucociliary clearance mechanism, marijuana-related impairment in the antimicrobial function of alveolar macrophages and/or fungal or bacterial contamination of marijuana. Patients with pre-existing immune deficits due to AIDS could be particularly susceptible to pulmonary infectious complications of marijuana use.


Keywords
Pulmonary function, cannabis, medical marijuana, HIV, AIDS

PDF do texto completo ]

Eventos Online 2020

Todas as informações sobre os Eventos IACM Online, incluindo vídeos gratuitos dos webinars com legendas em português, podem ser encontradas aqui.

Conferência 2021

A 12ª Conferência da IACM sobre Canabinóides em Medicina terá lugar online de 14 a 16 de Outubro de 2021. A inscrição é gratuita.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.