Vous êtes ici: Home > Therapeutics (ancienne) > Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System as a Trigger for Newborn Suckling

J Cannabis Ther 2002(3/4):049-60

Cannabinoids and Feeding

Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System as a Trigger for Newborn Suckling

Author
E. Fride

Abstract
Cannabinoids are known to enhance appetite by activating cannabinoid (CB1) receptors. This phenomenon is exploited to combat cachexia and loss of appetite in cancer and AIDS patients. The endocannabinoid 2-arachidonylglycerol (2-AG) is present in milk. Evidence is presented supporting a critical role for CB1 receptors in survival of mouse pups. Thus neonates do not gain weight and die within the first week of life when their receptors are blocked. This is due apparently, to an inability to ingest maternal milk. This suggests that the endocannabinoid-CB1 receptor system is unique in its absolute control over the initiation of the neonatal milk suckling response. It is further proposed that cannabis-based medicines should be developed to benefit infant failure to thrive.


Keywords
Cannabinoids, endocannabinoids, feeding, appetite, nursing, suckling, neonatal

Texte intégral au format PDF ]

Events Online 2020

Toutes les informations sur les événements en ligne de l'IACM, y compris les vidéos gratuites des webinaires sous-titrées en français, sont disponibles ici.

IACM Conference 2021

La 12e conférence de l'IACM sur les cannabinoïdes en médecine se tiendra en ligne du 14 au 16 octobre 2021. L'inscription est gratuite.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.