Você esta aqui:Home > Therapeutics (antigo) > Marijuana and Cannabinoids: Effects on Infections, Immunity, and AIDS

J Cannabis Ther 2001(3/4):061-85

Immune System

Marijuana and Cannabinoids: Effects on Infections, Immunity, and AIDS

Author
G.A. Cabral

Abstract
Marijuana and its major psychoactive component, delta-9-tetrahydrocannabinol (THC), alter resistance to bacterial, protozoan, and viral infections in vivo and in vitro. These alterations have been accompanied by modifications in functional components of the immune system. In addition, marijuana and THC, as well as other cannabinoids, have been reported to directly affect functional activities of lymphocytes, macrophages, natural killer cells, and other immunocytes. These include effects on cytokine production resulting in a shift in the balance of Th1 versus Th2 cytokines. Both receptor and non-receptor mediated modes of action have been proposed as causative of cannabinoid effects. Reports that marijuana and THC alter anti-microbial activity in vivo and in vitro indicate that its use presents a potential risk of decreased resistance to infections. However, few controlled longitudinal epidemiological and immunological studies have been undertaken to correlate the immunosuppressive effects of marijuana smoke or cannabinoids on the incidence of infections or disease in humans.


Keywords
AIDS, HIV, cannabinoid receptors, cannabinoids, delta-9-tetrahydrocannabinol, immunity, infections, marijuana, THC

PDF do texto completo ]

Eventos Online 2020

Todas as informações sobre os Eventos IACM Online, incluindo vídeos gratuitos dos webinars com legendas em português, podem ser encontradas aqui.

Conferência 2021

A 12ª Conferência da IACM sobre Canabinóides em Medicina terá lugar online de 14 a 16 de Outubro de 2021. A inscrição é gratuita.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.