Você esta aqui:Home > Therapeutics (antigo) > Endocannabinoid Degradation and Human Fertility

J Cannabis Ther 2002(3/4):035-47

Endocannabinoids

Endocannabinoid Degradation and Human Fertility

Author
M. Bari, N. Battista, A. Cartoni, G. D'Arcangelo, M. Maccarrone

Abstract
Anandamide (AEA) impairs mouse pregnancy and embryo development. Here, we overview the role of AEA in sexual function, focusing on AEA degradation during human pregnancy. Human peripheral lymphocytes express the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), which decreases in miscarrying women. FAAH is regulated by progesterone and Th1/Th2 cytokines, whereas the AEA transporter and the AEA binding cannabinoid receptors are not affected. Taken together, our results appear to add the endocannabinoids to the hormone-cytokine array involved in the control of human pregnancy, and suggest that FAAH might be a useful diagnostic marker for large scale, routine monitoring of gestation in humans.


Keywords
Anandamide, cytokines, endocannabinoids, human fertility, sex hormones

PDF do texto completo ]

Eventos Online 2020

Todas as informações sobre os Eventos IACM Online, incluindo vídeos gratuitos dos webinars com legendas em português, podem ser encontradas aqui.

Conferência 2021

A 12ª Conferência da IACM sobre Canabinóides em Medicina terá lugar online de 14 a 16 de Outubro de 2021. A inscrição é gratuita.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.