Você esta aqui:Home > Cannabinoids (antigo) > Cannabinoids and schizophrenia: where is the link?

Cannabinoids 2008;3(4):11-14 (9 November 2008)

Mini-review

Cannabinoids and schizophrenia: where is the link?

Kirsten Müller-Vahl

Clinic of Psychiatry, Socialpsychiatry & Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany, mueller-vahl.kirsten@mh-hannover.de

Highlighting the association between schizophrenia and cannabis sativa and the endogenous can-nabinoid receptor system, respectively, two opposite aspects are of major relevance. On the one hand, there is substantial evidence that cannabis has to be classified as an independent risk factor for psychosis that may lead to a worse outcome of the disease. This risk seems to be increased in genetically predisposed people and may depend on the amount of cannabis used. On the other hand, there are several lines of evidence suggesting that, at least in a subgroup of patients, altera-tions in the endocannabinoid system may contribute to the pathogenesis of schizophrenia, e.g., in-creased density of cannabinoid receptor type 1 (CB1) binding and increased levels of cerebrospinal fluid (CSF) anandamide. Accordingly, beside the „dopamine hypothesis“ of schizophrenia a „can-nabinoid hypothesis“ has been suggested. Interestingly, there is a complex interaction between the dopaminergic and the cannabinoid receptor system. Thus, agents that interact with the cannabinoid receptor system such as the non-psychoactive cannabidiol (CBD) have been suggested for the treatment of psychosis.

Keywords
Cannabis, THC, tetrahydrocannabinol, schizophrenia, psychosis

PDF do texto completo ]

Eventos Online 2020

Todas as informações sobre os Eventos IACM Online, incluindo vídeos gratuitos dos webinars com legendas em português, podem ser encontradas aqui.

Conferência 2021

A 12ª Conferência da IACM sobre Canabinóides em Medicina terá lugar online de 14 a 16 de Outubro de 2021. A inscrição é gratuita.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.