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IACM Monthly Meeting for Professionals June 2024
South Africa: A new law legalizes cannabis possession and cultivation by adults
On 28 May President Cyril Ramaphosa gave his approval to Cannabis for Private Purposes Act (CfPPA). The National Assembly had passed the legislation last November, and the National Council of Provinces signed off in February.
The reform has been years in the making, with lawmakers well past a deadline following a Constitutional Court ruling in 2018 that deemed the prohibition on simple possession and cultivation of cannabis to be unlawful, mandating legislative change within two years.
Science/Human: Long-term use of low doses of THC may improve chronic pain and related symptoms
METHODS: Adult Israeli patients licensed to use cannabis oil extracts for chronic pain were followed prospectively for 6 months.
RESULTS: The study included 218 patients at baseline, and 131 at 6 months. At 6 months, the mean daily doses of CBD and THC were 22 mg and 21 mg respectively. Pain decreased from 7.9 at baseline to 6.6 at 6 months. Of the 218 participants, 24% were "responders", who improved by at least 30% in pain.
CONCLUSION: This prospective cohort demonstrated a modest overall long-term improvement in chronic pain and related symptoms and a reasonable safety profile with the use of relatively low doses of individually titrated Δ9-tetrahydrocannabinol and cannabidiol.
Faculty of Social Welfare and Health Sciences, University of Haifa, Israel.
Science/Human: Cannabis use may be associated with a reduced risk for prostate cancer
Researchers undertook a cross-sectional study using National Survey on Drug Use and Health data from 2002 to 2020, involving 2503 participants in the USA.
Prostate cancer prevalence was lower among current cannabis users and former users compared to non-users.
These findings from a large national survey provide additional data to link cannabis use with lower ppstate cancer prevalence.
Department of Hematology-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
Science/Human: The cannabis spray Sativex is effective and safe in a large multicentre study
Methods: To investigate the effectiveness, tolerability and satisfaction of nabiximols in a real-life multicentre Swiss cohort as monotherapy or with stable doses of other antispastic medications, and explore clinical features which may predict treatment response.
Results: Ninety-five patients were included. From baseline to week 12, median Modified Ashworth Scale score decreased from 3.0 to 2.0.
Conclusions: Our first Swiss, multicentr, observational, real-life study supports and enhances previous finding of nabiximols as monotherapy and as add-on therapy, being an effective, safe and well-tolerated treatment option for resistant MS spasticity and spasticity-related symptoms (pain, bladder dysfunction and gait).
Multiple Sclerosis Center (MSC), Department of Neurology, Neurocenter of Southern Switzerland, Lugano, Switzerland.
Science/Human: Nanodispersible oral CBD solution may be helpful in anxiety disorders
METHODS: This phase 3 prospective, randomized, double blind, parallel group, placebo-controlled, 15-week cohort study took place at multiple sites across India. Eligible participants were randomly assigned to one of the two treatment arms (CBD or placebo) in a 1:1 ratio.
RESULTS: 178 participants were randomized to receive CBD (n=89) or placebo (n=89). There were improvements in anxiety and depression.
CONCLUSIONS: Nanodispersible CBD was therapeutically safe with no serious adverse events, well tolerated, and effective for the treatment of mild to moderate anxiety disorders, as well as associated depression and sleep quality disturbances.
Asha Hospital, Venkat Nagar, Banjara Hills,Hyderabad, Telangana, India.
Science/Human: CBD may improve pain in hand osteoarthritis
In this open-label feasibility trial, participants with symptomatically active hand osteoarthriis applied a novel transdermal CBD gel three times a day for four weeks to their most painful hand.
Eighteen participants were consented and 15 completed the trial. Pain ratings were significantly reduced over time from pre-treatment baseline including current pain and maximum pain. There were significant improvements in three quality of life measures: fatigue, stiffness and anxiety.
In summary, pain, grip strength and quality of life measures, using smartphone technology, was shown to improve over time following transdermal CBD.
The Lambert Initiative for Cannabinoid Therapeutics, The University of Sydney, Australia.
Science/Human: Cannabis use may not be associated with reduced physical activity
Methods: Data were obtained from the National Health and Nutrition Examination Survey from 2011 to 2014. We included adults in the United States who responded to a cannabis questionnaire and had at least 4 days of activity data from an accelerometer, which comprised participants from 18 to 59 years.
Results: Of 4666 included adults, 14% reported recent cannabis use. After covariate adjustment, recent cannabis use was not associated with daily sedentary time or daily physical activities
Conclusion: Recent cannabis use in young to midlife adults was not associated with accelerometer-measured sedentary or physical activity time.
Temerty Faculty of Medicine, University of Toronto, Canada.
Science/Human: Cannabis may be helpful in women with orgasm difficulties or dysfunction
METHODS: This observational study evaluated responses from female study participants relating to their demographics, sexual activities, mental well-being, cannabis usage, and orgasm-related questions from the Female Sexual Function Index.
RESULTS: Of the 1037 survey responses, 410 were valid and complete. Of the valid surveys, most women reported difficulty achieving orgasm during sexual activity with a partner. These women were primarily between 25 and 34 years of age.
Among participants who experienced challenges in achieving orgasm, 73% reported that cannabis use before partnered sex increased orgasm frequency, 67% stated that it improved orgasm satisfaction, and 71% indicated that cannabis use made orgasm easier.
International Institute of Clinical Sexology, Miami Shores, USA.
Science/Human: THC increases parasympathetic activity in neuropathic pain patients
METHODS: Twelve male patients with chronic radicular neuropathic pain participated in a randomized, double-blind, crossover, placebo-controlled trial.
RESULTS: THC significantly reduced the low frequency/high frequency heart rate variability ratio compared with placebo.
CONCLUSIONS: THC shifts the autonomic balance towards increased parasympathetic tone and improves inhibitory pain mechanisms in chronic pain. The increase in vagal tone correlates with connectivity changes in higher-order regulatory brain regions, suggesting THC exerts top-down effects.
Sagol Brain Institute, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Science/Human: Palmitoylethanolamide may help in irritable bowel syndrome
METHODS: This was a multicenter trial conducted at three Italian pediatric gastroenterology centers, employing a double-blind, placebo-controlled, parallel-arm design. Participants were ages 10 to 17 years and met criteria for pediatric irritable bowel syndrome. They received either a placebo or the endocannabinoid-like substance palmitoylethanolamide and polydatin.
RESULTS: The study involved 70 children with irritable bowel syndrome. As compared with the placebo group, the co-micronized therapy group had significantly more patients achieving complete remission after 12 weeks, with particular benefit in the diarrhea subtype. The treatment group also experienced a significant reduction in abdominal pain intensity and frequency compared with the placebo group.
Sapienza University of Rome, NESMOS Department, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Science/Human: There was no specific preference of certain cannabis strains depending on the disease
METHODS: This was an online survey conducted in Germany in 2020. Patients were allowed to participate only if they received a cannabis-based treatment from pharmacies in the form of cannabis flowers prescribed by a physician.
RESULTS: The survey was completed by 1,028 participants. Most participants (58%) have used medical cannabis for more than 1 year, on average, 5.9 different strains. Overall, the mean patient-reported effectiveness was 80%. A regression model revealed no association between the patient-reported effectiveness and the variety.
CONCLUSIONS: Patients self-reported very good efficacy and tolerability of cannabis. There was no evidence suggesting that specific strains are superior depending on the disease to be treated.
Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Science/Human: Cannabis improves quality of life in patients with multiple sclerosis
METHOD: Patients prescribed cannabis based medicines for multiple sclerosis symptoms for longer than one month were identified from the UK Medical Cannabis Registry.
RESULTS: 141 patients met the inclusion criteria for the study. There was an improvement in the following subscales of a quality of life questionnaire at 6 months: change in health scale, cognitive function, mental health composition, physical health, role limitations due to physical limitation and due to emotional problems, as well as social and sexual function.
CONCLUSIONS: This preliminary analysis demonstrates a possible association with improved general health-related quality of life in those prescribed CBMPs for MS.
Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK.
News in brief
Science/Animal: CBD shows protective effects on the liver
Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice.
Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Ma R, et al. Exp Biol Med (Maywood). 2024;249:10141.
Science/Human: The use of cannabis in Canada increased in people aged 65 and older.
Cannabis use in a Canadian long-term care facility: a case study.
College of Nursing, University of Manitoba, Winnipeg, Canada.
Balneaves LG,et al. BMC Geriatr. 2024;24(1):467.
Science/human: Cannabis use was associated with minimal changes in sleep architecture
The impact of cannabis use proximal to sleep and cannabinoid metabolites on sleep architecture.
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA.
Althoff MD, et al. J Clin Sleep Med. 2024 May 28. [in press]
Science/Cells: Phytocannabinoids show anticancer effects in neuroblastoma cells
Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells' viability and caspases 3/7 activation.
Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Playa Ancha, Valparaíso, Chile.
Tapia-Tapia E, et al. Biol Res. 2024;57(1):33.
Science/Animal: A CBD rich cannabis extract improved social interaction in mice
Cannabis Sativa Oil Promotes Social Interaction and Ultrasonic Communication by Acting on Oxytocin Pathway.
Department of Molecular and Translational Medicine, University of Brescia, Italy.
Premoli M, et al. 27. Cannabis Cannabinoid Res. 2024 May 27. [in press]
Science/Animal: Cannabidiol may attenuate psychological comorbidities in pain such as depression
Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: Role of prelimbic neocortex-hippocampal connections.
Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP, Ribeirão Preto, Brazil.
Medeiros AC, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2024:111039.
Science/Human: CBD may not enhance subjective experience in endurance exercise
The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial.
Lambert Initiative for Cannabinoid Therapeutics, The University of Sydney, Australia.
McCartney D, et al. Sports Med Open. 2024;10(1):61.
Science/Animal: The systemic bioavailability of CBD may be increased by 2 fold in bovine milk as well as infant formula
Infant formula as a solid lipid dose form for enhancement of the oral bioavailability of cannabidiol for paediatric patients.
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus, Parkville, Victoria, Australia.
Huang S, et al. Int J Pharm. 2024:124257.
Science: CBD analogues may be beneficial in triple negative breast cancer
Identification of Genes Hub Associated with Triple-Negative Breast Cancer and Cannabidiol Analogs Potential Inhibitory Agents: An In-silico Study.
GINUMED, Rafael Núñez University Corporation, Cartagena, Colombia.
Science/Review: A review outlines mechanisms of action of CBD that may be beneficial in Alzheimer’s disease
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer's Disease.
Department of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of Guelph, Canada.
Hickey JP, Collins AE, Nelson ML, Chen H, Kalisch BE. Curr Issues Mol Biol. 2024;46(5):4379-4402.
Science/Human: Researchers present Germany’s new cannabis act as a possible beginning of a new generation of European cannabis policies
Germany's cannabis act: a catalyst for European drug policy reform?
Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Manthey J, et al. Lancet Reg Health Eur. 2024;42:100929.
Science/Animal: Different cannabis cultivars may modulate different inflammatory mediators and pathways
Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies.
Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Fleisher-Berkovich S, et al. J Cannabis Res. 2024;6(1):25.
Science: CBD may be helpful in liver cancer treatment in combination with other agents
Cannabidiol and Aza-BODIPY Coencapsulation for Photodynamic Therapy Enhancement in Liver Cancer Cells.
Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Kampaengsri S, et al. ACS Appl Bio Mater. 2024 May 22. [in press]
Science/Animal: Repeated treatment with CBD favoured neuronal maturation of newborn nerve cells in the hippocampus in Parkinsonian rats
Cannabidiol improves nonmotor symptoms, attenuates neuroinflammation and favors hippocampal newborn neuronal maturation in a rat model of Parkinsonism.
Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná, Brazil.
Mattos BA, etal. Acta Neuropsychiatr. 2024:1-30.
Science/Human: Patients undergoing coronary artery bypass surgery treated with THC were able to reduce opiate use by 40%
Perioperative Cannabinoids Significantly Reduce Postoperative Opioid Requirements in Patients Undergoing Coronary Artery Bypass Graft Surgery.
Clinical Medicine, University of Cambridge, GBR.
Kumar U, et al. reus. 2024;16(4):e58566.
Science/Animal: In studies with mice the effects of electroacupuncture involved the CB1 receptor
Effect of electroacupuncture at "Neiguan" (PC6) on pain and brain orexin 1 receptor in mice with inflammatory pain.
Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.
Ma NQ, et al. Yan Jiu. 2024;49(5):441-447.
Science/Review: Investigators discuss the possible mechanisms involved in the antidepressant effects of CBD
New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect.
Department of Biomedicine, Aarhus University, Denmark.
Guldager MB, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2024:111029.
Science/Animal: Both the CB2 receptor as well as the PPAR-Gamma receptor mediate the anti-inflammatory effects of CBD in a model of inflammation
Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ.
Federal University of Health Sciences of Porto Alegre, Rio Grande do Sul, Brazil.
Rodrigues FDS, et al. Neurochem Int. 2024;177:105769.
Science/Cells: Several phytocannabinoids including cannabigerol, cannabichromene and cannabinol showed anticancer effects in multiple myeloma
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma.
School of Pharmacy, University of Camerino, Camerino, Italy.
Aguzzi C, et al. Biofactors. 2024 May 17. [in press]
Science/Animal: Cannabis extracts may be helpful in the treatment of neuropathic pain induced by paclitaxel
The Potential Antinociceptive Effect and Mechanism of Cannabis sativa L. Extract on Paclitaxel-Induced Neuropathic Pain in Rats Uncovered by Multi-Omics Analysis.
National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai, China.
Xu Y, et al. Molecules. 2024;29(9):1958.
Science/Animal: In studies with mice CBD was helpful in post-traumatic stress disorder by reducing inflammation of the nerve cells
Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice.
Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Xie G, et al. Brain Behav Immun. 2024;119:945-964.
Science/Human: There was no next day impairment of 10 mg THC and 200 mg of CBD in simulated driving
Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial.
Woolcock Institute of Medical Research, Macquarie University, Sydney, Australia.
Suraev A, et al. Psychopharmacology (Berl). 2024 May 17. [in press]
Science/Human: According to a large survey doctors noted an improvement of symptoms by cannabis-based products in at least 75% of patients suffering from different conditions
Cannabinoid Drugs in the Treatment of Psychiatric Disorders - Data from the German Federal Institute for Drugs and Medical Devices]. [Article in German; Abstract available in German from the publisher.
Klinik für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin Campus Charite Mitte, Berlin, Germany.
Wülfing F, et al. Psychiatr Prax. 2024 May 15. [in press]
Science/Animal:The phytocannabinoids cannabidivarin and Cannabigerol may interfere with placentation and pregnancy outcomes
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells.
Applied Molecular Biosciences Unit, University of Porto, Portugal.
Alves P, et al. Arch Toxicol. 2024 May 15. [in press]
Science/Cells: So-called policosanols in hemp may be useful against inflammation
Extraction, purification and in vitro assessment of the antioxidant and anti-inflammatory activity of policosanols from non-psychoactive Cannabis sativa L.
Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Caroli C, et al. Heliyon. 2024;10(9):e30291.
Science/Animal: In a study with rats transdermal delivery of CBD was improved by a new drug delivery system
Nanosuspension-Loaded Dissolving Microneedle Patches for Enhanced Transdermal Delivery of a Highly Lipophilic Cannabidiol.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry of Chinese Academy of Sciences, Beijing, People's Republic of China.
Cheng A, et al. Int J Nanomedicine. 2024;19:4061-4079.
Science/Animal: Nutrition during pregnancy had an effect on the endocannabinoid system in rats
Fish oil supplementation during pregnancy decreases liver endocannabinoid system and lipogenic markers in newborn rats exposed to maternal high-fat diet.
Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
Fassarella LB, et al. Eur J Nutr. 2024 May 10. (in press]
Science/Cells: In a study with breast cancer cell lines researchers found a novel mechanism of cannabinoid-induced cell death
Mitochondrial calcium overload contributes to cannabinoid-induced paraptosis in hormone-responsive breast cancer cells.
Department of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, South Africa.
de la Harpe A, et al. Cell Prolif. 2024:e13650.
Science/Animal: In studies with mice CBD induced toxicity in pancreatic cancer cells involving ceramide
Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress.
Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK.
Mangal N, et al. J Cannabis Res. 2024;6(1):22.
Science/Human: The combination of cannabis and nicotine in pregnancy may be associated with an increased risk of infant death
Risk of Adverse Neonatal Outcomes After Combined Prenatal Cannabis and Nicotine Exposure.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, USA.
Crosland BA, et al. JAMA Netw Open. 2024;7(5):e2410151.
Science/Cells: CBD upregulates so-called Stress granules in glioblastoma cells causing anti-cancer effects
Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma.
DCG Center for Excellence in Research, Scholarship and Innovation (CERSI), Augusta University, Augusta, USA.
Wang LP, et al. Med Oncol. 2024;41(6):140.
Science/Animal: In a study with rats CBD and THC showed no inhibitory effects on bone healing
The effect of cannabinoids on single-level lumbar arthrodesis outcomes in a rat model.
Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Fogel H, et al. Spine J. 2024:S1529-9430(24)00217-1.
Science/Animal: In a study with mice terpenes of the cannabis plant have analgesic effects
Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors.
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, United States.
Schwarz AM, et al. Pain. 2024 May 2. [in press]
Science/Animal: In a study with nematodes cannabinoids were shown to lengthen lifespan
Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans.
Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Australia.
Wang Z, Arnold JC. Geroscience. 2024 May 2. [in press]
Science/Animal: A cannabis extract showed beneficial effects in a mouse model of post-traumatic stress disorder
Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway.
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Shen B, et al.Behav Brain Res. 2024;467:115005.
Science/Animal: The CB2 receptor agonist beta--caryophyllene may reduce heroin self administration
β-caryophyllene inhibits heroin self-administration, but does not alter opioid-induced antinociception in rodents.
Department of Psychological and Brain Sciences, Colgate University, Hamilton, USA.
Galaj E, et al. Neuropharmacology. 2024;252:109947.
Science/Animal: CBD may reduce cognitive impairment in Alzheimer’s disease
Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis.
Basic Medical and Forensic Medicine, Baotou Medical College, Inner Mongolia, China.
Ma BQ, et al. 8. J Toxicol Environ Health A. 2024;87(11):471-479.
Science/Human: CBD had no effects on exercise
Influence of short-term chronic oral cannabidiol application on muscle recovery and performance after an intensive training protocol - a randomized double-blind crossover study.
German Sport University Cologne, Department of Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, Cologne, Germany.
Isenmann E, et al. 4. J Int Soc Sports Nutr. 2024;21(1):2337252.
Science/Animal: The activation of the CB1 and the CB2 receptor may be beneficial in frontoparietal dementia
Involvement of CB(1) and CB(2) receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.
Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Gonzalo-Consuegra C, et al. Biomed Pharmacother. 2024;174:116473.
Science: CBD may enhance the anti-cancer effects of platinum drugs and overcome drug resistance
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, PR China.
Wei T, et al. J Inorg Biochem. 2024;254:112515.
Science/Animal: Agonists of cannabinoid receptors exert antileukaemic effects
Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions.
Instituto de Biomedicina de Sevilla (IBIS/CSIC), Universidad de Sevilla, Spain.
Medrano M, et al. Br J Cancer. 2024;130(9):1529-1541.
Science/Animal: CBD exhibits therapeutic potential for traumatic brain injury related dysfunction
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Department of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, China.
Ling T, et al. 1. Neuroscience. 2024;545:31-46.
Science/Animal: In studies with mice sleep deprivation causes pain, which may be reduced by CBD
Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia.
Hebei Medical University, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei, China.
Zhu K, et al. Neuropharmacology. 2024;249:109893.
Science/Animal: A certain Chinese herb activates the CB1 receptor and reduces pain in zebrafish
Therapeutic potential of CB(1)R activation by Qingyangshen glycoside M1 for seizure relief.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, PR China.
Mu X, et al. J Ethnopharmacol. 2024;327:117982.
Science/Animal: CBD may reduce the cellular uptake of lead and reverses inflammation induced by lead
Evaluation of the effect of cannabidiol on the THLE-2 liver cell line exposed to lead.
Department of Medical Pharmacology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Şahin S, et al. 5. Sci Total Environ. 2024;923:170901.
Science/Animal: In a study with rats CBD was able to mitigate MTX induced lung damage
The effects of cannabidiol against Methotrexate-induced lung damage.
Faculty of Veterinary Medicine, Department of Pathology, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.
Ozmen O, et al. Basic Clin Pharmacol Toxicol. 2024;134(5):695-703.
Science/Animal: According to studies with mice a certain CBD derivative may be helpful in alleviating symptoms of schizophrenia
Therapeutic-like activity of cannabidiolic acid methyl ester in the MK-801 mouse model of schizophrenia: Role for cannabinoid CB1 and serotonin-1A receptors.
Memorial University of Newfoundland and Labrador, St. John's, Newfoundland, Canada.
Richardson B, et al. Eur J Neurosci. 2024;59(9):2403-2415.
Science/Animal: According to studies with rats CBD may have different functional effects in the fetal compared to the adult brain
Entry of cannabidiol into the fetal, postnatal and adult rat brain.
Department of Neuroscience, Monash University, Melbourne, Australia.
Fitzpatrick G, et al. Cell Tissue Res. 2024;396(2):177-195.
Science/Human: According to a study with about 48,000 patients regular cannabis use was associated with an increased preoperative opioid use
Risks associated with chronic cannabis use on opioid use, length of stay, and revision rate for patients undergoing posterior lumbar interbody fusion.
Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, USA.
Brenne J, et al. 3. Spine J. 2024;24(5):851-857.
Science/Animal: According to studies with mice CBD may be helpful in insomnia
Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT(1A) Receptor.
Shenyang Pharmaceutical University, Shenyang, China.
Liu YM, et al. 7. Neurochem Res. 2024;49(5):1150-1165.
Science/Human: Cannabis use may have different effects on neurocognitive functioning: reduced attention and verbal memory, but improved working memory, visual memory and emotional recognition
Does cannabis affect cognitive functioning in patients with schizophrenia?
Laboratory of Clinical Neuroscience and Mental Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Rachid H, et al. Schizophr Res Cogn. 2023;36:100299.
Science/Human: Nightly supplementation with 150 mg CBD did not cause effects on sleep compared to placebo
Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing.
Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, Australia.
Narayan AJ, et al. J Clin Sleep Med. 2024;20(5):753-763.
Science/Animal: The endocannabinoid system is involved in the analgesic effects by acupuncture
Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain.
Department of Acupuncture and Moxibustion, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.