You are here: Home > J Cannabis Ther > Endocannabinoid Degradation and Human Fertility

J Cannabis Ther 2002(3/4):035-47

Endocannabinoids

Endocannabinoid Degradation and Human Fertility

Author
M. Bari, N. Battista, A. Cartoni, G. D'Arcangelo, M. Maccarrone

Abstract
Anandamide (AEA) impairs mouse pregnancy and embryo development. Here, we overview the role of AEA in sexual function, focusing on AEA degradation during human pregnancy. Human peripheral lymphocytes express the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), which decreases in miscarrying women. FAAH is regulated by progesterone and Th1/Th2 cytokines, whereas the AEA transporter and the AEA binding cannabinoid receptors are not affected. Taken together, our results appear to add the endocannabinoids to the hormone-cytokine array involved in the control of human pregnancy, and suggest that FAAH might be a useful diagnostic marker for large scale, routine monitoring of gestation in humans.


Keywords
Anandamide, cytokines, endocannabinoids, human fertility, sex hormones

PDF of the full text ]

IACM Conference 2019

The IACM Conference 2019 will be held on October 31 - November 2, 2019, at Estrel Hotel, Berlin, Germany. More information coming soon! Please see here information on past conferences.

Supported conferences

STCM Conference, 19 January 2019, University Hospital Bern, Switzerland

Cann10, 14-16 October 2018, Tel Aviv Israel.
 

Members only

Please click here to visit the Members Only Area with a film to honour Prof Raphael Mechoulam, 
Please click here to become a member.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.