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Alex J. 04/04/2009 11h00

Cannabidiol CBD et maladies neurodégénératives
Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

Teresa Iuvone
1,, Giuseppe Esposito2, Daniele De Filippis1,, Caterina Scuderi2 & Luca Steardo2
1 Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples “Federico II,” Naples, Italy
2 Department of Physiology and Pharmacology “V. Erspamer,” University of Rome “La Sapienza”, Piazzale Aldo Moro, Rome, Italy

Endocannabinoid Research Group

Neurodegenerative diseases represent, nowadays, one of the main causes of
death in the industrialized country. They are characterized by a loss of neurons
in particular regions of the nervous system. It is believed that this nerve cell loss
underlies the subsequent decline in cognitive and motor function that patients
experience in these diseases. A range of mutant genes and environmental toxins
have been implicated in the cause of neurodegenerative disorders but the
mechanism remains largely unknown. At present, inflammation, a common
denominator among the diverse list of neurodegenerative diseases, has been
implicated as a critical mechanism that is responsible for the progressive nature
of neurodegeneration. Since, at present, there are few therapies for the
wide range of neurodegenerative diseases, scientists are still in search of new
therapeutic approaches to the problem. An early contribution of neuroprotective
and antiinflammatory strategies for these disorders seems particularly
desirable because isolated treatments cannot be effective. In this contest, marijuana
derivatives have attracted special interest, although these compounds
have always raised several practical and ethical problems for their potential
abuse. Nevertheless, among

Cannabis compounds, cannabidiol (CBD), which
lacks any unwanted psychotropic effect, may represent a very promising agent
with the highest prospect for therapeutic use.

Article complet :

Une étude de 2004 avait confirmé l'effet également anxyolitique du CBD :

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